How Does Adderall Work in the Brain? Adderall Euphoria and the Proper Use of Adderall
What is Adderall, and how does Adderall work in the human brain? A common question on the web, Adderall typically works in the brain by influencing powerful neurotransmitters that influence focus, motivation, mood and energy levels, of which the gist of include dopamine, serotonin, and norepinephrine, among a host of others to a much lesser degree. Whether you’re using Adderall directly for ADHD and actually need the drug, or if you’re a college student that’s taking the drug almost as a nootropic to get through final exams (this is very risky and I don’t recommend this, but at the same time I totally understand if you are…gotta do what you gotta do), learning what Adderall does in the brain and specifically how it affects chemicals and neurotransmitters in order to influence the mind, is the first major step to controlling the drug, managing it properly, and keeping away from increased tolerance and the risk of addiction.
In short, by educating yourself about Adderall while you’re taking it, you control Adderall before it controls you, one of the most important steps to regular use of the drug, and the purpose for me writing this article. For more information, subscribe to our blog for a free sample of nootropics worth over fifty dollars, and be sure to comment down below with your questions or concerns on the article and we’ll get back to you within one business day, as this post is sure to be quite the controversial article. Aside from that enjoy the article, and be sure to tune in daily for 3000 word blog posts about a fresh, new topic built in controversy surrounding nootropics!
Other websites and nootropics blogs that talk about this and similar topics and issues include:
Absorb your Health and Absorb your Health Review Websites
Modup.net and Modup.net Review Blogs
Smart Drugs for College
Smart Drug Smarts
Nootropic Nation and the Mind Institute
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What is Adderall, and How Does Adderall Work?
Adderall is a schedule II prescription stimulant in the United States and in most countries abroad that’s primary purpose is for use in treating ADHD (attention deficit hyperactivity disorder) or ADD (attention deficit disorder), and that has a frequent off-label use for fatigue, weight-loss, in the case of patients dealing with obesity, and in those users of who are struggling with other similar and related issues. With all this in mind, how does Adderall work specifically in the brain, in order to bring about these effects and treatments. Generally speaking, Adderall works by influencing certain neurotransmitters in the brain, blocking their reputake and pushing a higher amount of them to critical regions where they can be useful, such as the prefrontal lobe cortex, the primary area of the brain responsible for focus and working memory, and the major areas that disorders like ADHD and ADD effect.
There is a huge amount of research on Adderall and the neurotransmitters that the drug influences directly in humans. The drug is FDA approved, meaning that scores of studies have been done on mice and rats, as well as on humans for decades and decades to prove the drugs effectiveness before it was released as an approved prescription drug to the general public. The major research studies are as follows:
Adderall has loads of clinical trial research on it, and is considered a very safe drug when regular use is monitored by a doctor, and when the user in question that is taking the drug is dealing with ADHD, ADD, fatigue, or some other related disorder in which the user actually needs the prescription stimulant. For those taking it either with a prescription or without, and for users who in-fact don’t necessarily need the drug, you’re doing yourselves more harm than good, and you’re much better off not using the drug than using it over the long haul.
What is the Best Dosage of Adderall, and How Does Adderall Work at a 30mg Dosage?
The best dosage of Adderall is obviously the one that is prescribed by your doctor, however generally speaking this dosage is going to be somewhere in the range of 10-60 milligrams once per day in the morning. Dosage will depend on the opinion of your doctor, as well as your age, weight, tolerance and experience level with regards to how the drug effects you. Starting users will generally being with around ten milligrams, gradually increasing their dosage very 6-12 months until their doctor feels that a ceiling dosage is now present.
The reason for doing this and the answer to how Adderall works in the brain regarding tolerance and dosing, is that at first, Adderall will be hugely powerful and create a really strong euphoria even at a low dosage. However after days, weeks, months and even years of using the drug, the natural defense mechanism of the brain kicks in and goes “okay we can’t keep putting out this same output day in and day out or this receptor is going to burn out pretty fast, let’s down regulate this so it pumps out less than normal amounts of dopamine on a regular basis-this way when he takes the drug he’ll be back at around baseline and they’ll be no harm done.” When this happens, you need higher and higher amounts of the drug in order to get the same effect, which is why your doctor will gradually increase your dosage over time.
As the writer of a nootropics blog, I would be remiss if I did not mention that Adderall is quite frequently stacked with a host of other nootropics and Smart Drugs in order to increase its potency. Whether or not this is effective, smart or even dangerous is up for debate, but with this in mind, the list of nootropics is as follows:
Piracetam-The original nootropic, Piracetam was developed in the 1960’s as the first brain enhancement supplement, and was meant to improve memory, mood, focus, motivation and overall energy levels. Since its creation, it has spawned off dozens of related nootropics like it.
Aniracetam-Five times more powerful than Piracetam and with a significant anti-anxiety effect that Piracetam lacks. Very popular as a supplement among keynote speakers, entrepreneurs, and among those in high pressure jobs.
Oxiracetam-Known as the speedy Racetam, Oxiracetam improves focus to a significant degree due to its effects on the neurotransmitter dopamine in the brain. Be sure to take it with a choline source to both potentiate it and prevent headaches.
Pramiracetam-Thirty times more powerful than Piracetam, Pramiracetam helps improve mood, memory and focus to a significant degree, and is the strongest natural Racetam on the market without any added molecules.
Phenylpiracetam-Forty times stronger than Piracetam overall and with an added Phenyl molecule that makes the drug also have an effect on dopamine-hugely popular in the United States, the United Kingdom, India, China and Europe.
Noopept-One thousand times more powerful than Piracetam, Noopept helps to improve mood, memory and a user’s overall ability to focus and learn information.
CDP Choline-The most popular form of choline on the market.
Alpha GPC Choline-The strongest form of choline available, found in popular nootropic stacks like Ciltep and Onnit’s brand name nootropic stack “Alpha Brain.”
Centrophenoxine-A unique form of CDP Choline with an added DMAE extract to the mix.
Uridine Monophosphate-An extended release form of CDP Choline. It is essentially a slightly weaker but longer lasting form of the supplement.
Ashwagandha-The most popular Adaptogen supplement on the market for lowering stress levels.
Rhodiola Rosea 3% Salidroside-Twice as strong as Ashwagandha as an adaptogen.
Vitamin B12-Very frequently stacked with Adderall for its ability to lower the side effects of it, increase its potency and make it last longer.
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How Long Does Adderall Last?
The length of time in which Adderall lasts is hugely related to how Adderall works, and the duration of time in which Adderall lasts is typically based strongly on the duration of time in which the drug has been used (one’s overall tolerance to the drug) as well as the dosage of the product in question. Typically, the length of duration in which Adderall lasts is going to be as follows
-Ten Milligrams of Adderall IR-Typically lasts around six hours.
-Ten Milligrams of Adderall XR-Lasts around eight hours, but this amount of time is greatly diminished with regular and everyday use.
-Twenty Milligrams of Adderall IR-Eight to ten hours.
-Twenty Milligrams of Adderall XR-9 to 10 hours.
-Thirty Milligrams of Adderall IR-Ten to twelve hours on a single dosage, this is the time needed for the entire drug to wear off so that you can sleep. With regards to when the effects will start wearing off, it is closer to ten hours.
-Thirty Milligrams of Adderall XR-Can last from ten to fifteen hours, and the time will diminish significantly with increased tolerance.
-Sixty Milligrams of Adderall IR-This is really an extremely high dosage of Adderall and should never be taken all at once. This is the highest prescribed dosage, and while I don’t recommend going this high, if you’re going to spread it out throughout the day and definitely not all at once, otherwise side effects and overdose can and may occur. Always do your own research before taking a new prescription or nootropic supplement, caution is truly the name of the game when introducing any foreign substance to the body, and especially on those supplements that are meant to influence the mind.
-Sixty Milligrams of Adderall XR-This is going to last 24 hours unless you’ve got a serious tolerance to Adderall built up from either prior or continuous use. Again, this is too high and I would not recommend unless you’ve been under regular, trusted care of a licensed and noteworthy physician.
As mentioned in the definitions above, once again these are estimates and are subject to change based on a users weight, age, tolerance level, experience level, and the like. When nootropics are stacked into the equation, there is really no telling how long the cocktail can last, and trial and error is the only real way to know. Further paragraphs will look at the question of “how does Adderall work,” with relation to those users that are new to the drug, as well as those users that are more experienced with it.
Adderall vs Nootropics
Compared to nootropics, while Adderall is FDA approved and Nootropics are not, Adderall is in my opinion still the more dangerous drug of the two, albeit probably the more effective. Adderall is a prescription stimulant for ADHD, and as an amphetamine, I can attest that it is pretty hardcore with regards to improving a users overall brain function. It gets its effects off of increasing the dopamine, serotonin and nor-epinephrine receptors in the brain, while nootropics typically work on GABA, acetylcholine, Glutamate and serotonin receptors, and to a much lesser degree. The receptors that nootropics activate are much less addictive, however typically speaking the one’s that Adderall activates are more effective. With regards to total safety however, nootropics are an effective alternative to prescription stimulants.
Adderall Use as a Nootropic Among College Students
Adderall use has skyrocketed among college students in University, with students taking the drug as a kind of “Smart Drug,” off-label and for tests and papers, when this is truly not the purpose that the drug was entirely intended for. For the college students out there that are doing this, there is a better and safer way (not to mention LEGAL) through nootropics, so I say to you, nearly beg you, do not risk your life and freedom by abusing Adderall, look into Piracetam, Aniracetam, Phenylpiracetam and Alpha GPC Choline as effective alternatives to the drug. With regards to its use as a nootropic, how does Adderall work in the brain among those that are new to the drug, and how can you effectively use Adderall without risk of addiction or excess side effects? Read on to find out more on the issue.
How Does Adderall Work in New Users?
In new users, Adderall is truly significant in the brain. Since the brain’s receptors are fresh to the drug, having never tasted an amphetamine before, the first weeks and even months that you take Adderall (depending on your weight, cross-tolerance from related stimulants, and the amount of vacation days you take from Adderall), the effects from Adderall are going to be quite euphoric, and will feel something like that scene from the movie “Limitless,” where he gets the whole bag of NZT, goes home and takes the pill and walks out of his house super euphoric. While the movie is obviously exaggerated in this respect, in total honesty the first few times that you take the drug this is going to be what it feels like. With all these great effects, the question soon arises of how does Adderall work in the brain to create such an effect? Well what essentially happens is that Adderall pushes important neurotransmitters, like dopamine, to the frontal lobes of your brain where they are better used for focus, memory and motivation. When all of these are combined together, you get a euphoria as a by-product.
How Does Adderall Work in Long-Term Regular Users?
In long-term and more regular users, the way in which Adderall works is a bit different. Say we have a user that has been taking Adderall for over 6 months on a daily basis, how does Adderall work in this users’s brain compared to the newbie still in the euphoric stage that we mentioned in the previous paragraph? Well given that the older user is going to have much more of a tolerance built up, he is going to need more of the drug to get the same effect, and as such when he takes a regular amount, say a similar amount that that of the one that he did six months ago, no ensuing euphoria and crazy manic Adderall high is going to result, and instead he is merely going to achieve a more baseline state, granite this new baseline will still be higher on the Adderall than it was when he was off of it. This is actually why Adderall is prescribed in patients with ADD and ADHD, the drug wasn’t meant to help college kids cram for tests, or to jack users up to the point of staying up late and pulling all nighters, its meant to help patients who actually need the drug with ADHD to function by increasing their overall baseline state to a level that is more consistent with what a patient without ADHD would have.
How Does Adderall Work to Help Users Focus and Learn More Quickly?
Adderall helps users learn and focus at a rate that is much faster than normal because dopamine and focus in general are the main ways that people learn. Dopamine helps to reinforce a task making it in a sense “fun,” yet also increasing a users ability to focus. Focus is the primary key to learning anything, whether its calculus or trigonometry, to writing a novel or starting a blog, to getting work done on your business. Whatever the task is, the key to real focus, learning a concept or learning a skill, is focus, focus and focus again. For many ADHD patients that begin to take Adderall, a lot of them say things like “the lights turned on,” or “I could finally learn at a reasonable pace.” Focus is the primary key to learning any skill or topic, so for this reason Adderall can really be a life saver for those users that are struggling with ADHD (or for college students that need a leg up on exams.)
How Does Adderall Work in Attention Deficit Disorder (ADHD) Patients?
As mentioned in the previous paragraph, Adderall works differently in ADHD patients than in those patients who either don’t have the illness, or who are using the drug for recreational purposes. For ADHD patients, Adderall works by increasing the users baseline state, and by keeping their brain receptors at levels resembling that of something closer to a normal individual without ADHD. The increased speed and ability to learn and focus is the finished result of Adderall’s work in the brain.
The Research Behind How Exactly Adderall Works in the Brain, The Magic of Neurotransmitters
So given the last 2800 words or so of this article, let’s wrap it up by looking at the specifics of the question of “how does Adderall work in the brain,” one last time. Adderall works on several key receptors in order to increase focus in the user, whether they have ADHD or not. The group of receptors that Adderall manipulates and increases is as follows:
Dopamine-The primary neurotransmitter that creates Adderall’s function, dopamine helps to reinforce positive tasks, as well as improve focus, mood, memory and motivation.
Norepinephrine-The levoamphetamine portion of Adderall (as Adderall is actually 75% Dextroamphetamine and 25% Levoamphetamine), is what influences this receptor, and is what causes the “kick in the pants,” type feeling that Adderall gives users. With regards to the spike in heart rate and the actual physical effects that Adderall has, this neurotransmitter is the primary reason why.
Serotonin-Adderall increases serotonin more as a by-product of its increase of dopamine, as the two are almost always found together in users. Serotonin actually helps a little bit to balance out the effects of the stimulant and excitation neurotransmitters that Adderall affects.
Final Thoughts on the Question of “How Does Adderall Work?” and How you can Play with Fire and Use it to Your Advantage
In conclusion, the way in which Adderall works is no longer a mystery, and given the vast knowledge of modern science, we now know exactly how Adderall functions in the brain. Adderall works by increasing a cocktail of neurotransmitters, blocking their re-uptake and pushing them to parts of the brain in higher amounts where they can be used more effectively, such as the frontal lobes and prefrotnal lobe cortex in ADHD patients brains. Adderall is a schedule II prescription drug in the United States and in most countries abroad, and should never be used by those without a prescription. For college students looking for a safer and more long-term alternative to cognitive enhancement rather than Adderall and the abuse of other prescription stimulants, they can turn to Nootropics like Piracetam and Noopept for a truly safe and powerful cognitive boost. For more information on the question of “how does Adderall work,” as well as other related Smart Drugs, subscribe for a free sample of nootropics worth over fifty dollars, and comment down below with your thoughts and opinions on the article and we’ll get back to you within a business day. Until next time, you heard it first right here at Nootropics University.com.
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